From Microbes to Prions
نویسندگان
چکیده
منابع مشابه
From Microbes to Prions The Final Proof of the Prion Hypothesis
Much like the "microbe hypothesis" put forth over 150 years ago, the "prion hypothesis" can be definitely proven only if a prion disease is engendered in a natural host from an infectious prion produced in vitro. In this issue of Cell, come very close to accomplishing this goal by producing a prion disease in a natural host from a prion entirely generated in vitro using a PCR-like amplification...
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I entered the prion field in the early 1990s, when the nature of the infectious agent was still in dispute. At one of the very first scientific meetings I attended, a spirited argument broke out between the proponents of a viral etiology and the proponents of the protein-only (prion) etiology. One of the strong arguments made that day against the protein-only hypothesis was the observation that...
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Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules. These contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage. Neutrophils circulate in the blood as dormant cells. At sites of infection, endothelial cells capture...
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Concretely, the dynamics of this Genomics/Proteomics coupling is appeared as two correlated curves translating topology and the dynamic evolution of a hierarchical classification of codons throughout the studied sequence. More precisely, the study of these curves shows that this tool highlights the functional areas and active sites within proteins. The specific context of Prions area could be a...
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A steady and continuous supply of energy will be pivotal if we are to sustain the infrastructure necessary for the current and future development of modern societies. Almost 80% of our current energy supply is derived from the combustion of fossil fuels and, even taking into account the discovery of new reserves, it is predicted that fossil fuel supplies will be severely depleted over the next ...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.04.002